Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.690


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPAchr21_+_271077310.531.8e-01Click!
ELK4chr1_-_2056019990.472.4e-01Click!
ELK1chrX_-_475099930.413.2e-01Click!
GABPB1chr15_-_506473850.393.4e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_15872905 3.259


chrX_-_15872921 3.234 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_22351984 2.707 LINC00339
long intergenic non-protein coding RNA 339
chrX_-_15872882 2.638 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr5_+_180650233 2.520 NM_033549
NM_201627
TRIM41

tripartite motif containing 41

chr2_+_109745996 2.505 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr5_+_180650274 2.449 TRIM41
tripartite motif containing 41
chrX_-_106959597 2.305 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr13_-_33760215 2.266 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chrX_-_153775774 2.200 NM_001042351
G6PD
glucose-6-phosphate dehydrogenase
chr5_+_180650709 2.181 TRIM41
tripartite motif containing 41
chr6_+_30524662 2.177 PRR3
proline rich 3
chrX_-_153775427 2.143 G6PD
glucose-6-phosphate dehydrogenase
chr12_-_105629790 2.121 NM_001251904
NM_018171
APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chrX_-_15872938 2.120 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_46722139 2.084 ARHGAP1
Rho GTPase activating protein 1
chrX_-_15872871 2.013 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_38034357 2.006 BAG4
BCL2-associated athanogene 4
chr9_-_88969256 1.988 ZCCHC6
zinc finger, CCHC domain containing 6
chr10_-_1102643 1.979 IDI1
isopentenyl-diphosphate delta isomerase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 204 entries
enrichment   p-value GO term description
3.68 3.15e-02 GO:0006376 mRNA splice site selection
2.84 4.66e-03 GO:0000245 spliceosome assembly
2.81 1.97e-02 GO:0000387 spliceosomal snRNP assembly
2.81 1.97e-02 GO:0006903 vesicle targeting
2.51 2.57e-07 GO:0006415 translational termination
2.49 3.20e-18 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.49 3.20e-18 GO:0000398 nuclear mRNA splicing, via spliceosome
2.48 2.37e-18 GO:0000375 RNA splicing, via transesterification reactions
2.45 3.85e-02 GO:0006369 termination of RNA polymerase II transcription
2.43 4.04e-06 GO:0019080 viral genome expression
2.43 4.04e-06 GO:0019083 viral transcription
2.43 6.09e-06 GO:0022618 ribonucleoprotein complex assembly
2.42 3.45e-07 GO:0043241 protein complex disassembly
2.42 3.45e-07 GO:0043624 cellular protein complex disassembly
2.40 4.36e-06 GO:0071826 ribonucleoprotein complex subunit organization
2.39 1.80e-02 GO:0050434 positive regulation of viral transcription
2.38 4.31e-04 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.38 1.49e-03 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.38 1.49e-03 GO:0072395 signal transduction involved in cell cycle checkpoint
2.38 1.49e-03 GO:0072401 signal transduction involved in DNA integrity checkpoint

Gene overrepresentation in compartment category:

Showing 1 to 20 of 59 entries
enrichment   p-value GO term description
3.83 2.23e-02 GO:0005732 small nucleolar ribonucleoprotein complex
3.26 6.48e-04 GO:0005689 U12-type spliceosomal complex
3.17 2.57e-05 GO:0030532 small nuclear ribonucleoprotein complex
2.67 3.92e-09 GO:0071013 catalytic step 2 spliceosome
2.48 5.95e-13 GO:0005681 spliceosomal complex
2.48 3.50e-02 GO:0022627 cytosolic small ribosomal subunit
2.38 2.54e-04 GO:0015934 large ribosomal subunit
2.28 1.24e-04 GO:0022626 cytosolic ribosome
2.23 2.24e-03 GO:0000502 proteasome complex
2.20 1.33e-34 GO:0030529 ribonucleoprotein complex
2.20 2.23e-03 GO:0030117 membrane coat
2.20 2.23e-03 GO:0048475 coated membrane
2.16 4.91e-11 GO:0005840 ribosome
2.07 1.25e-05 GO:0016607 nuclear speck
2.06 2.70e-03 GO:0000790 nuclear chromatin
2.03 5.66e-07 GO:0044445 cytosolic part
1.97 2.85e-09 GO:0016604 nuclear body
1.89 2.28e-04 GO:0000151 ubiquitin ligase complex
1.89 9.50e-03 GO:0005925 focal adhesion
1.80 3.64e-02 GO:0005924 cell-substrate adherens junction

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
2.20 4.84e-09 GO:0003735 structural constituent of ribosome
1.67 5.92e-18 GO:0003723 RNA binding
1.65 9.55e-04 GO:0019787 small conjugating protein ligase activity
1.64 2.59e-03 GO:0004842 ubiquitin-protein ligase activity
1.60 1.04e-02 GO:0003713 transcription coactivator activity
1.56 5.13e-03 GO:0016881 acid-amino acid ligase activity
1.52 8.13e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.49 2.22e-03 GO:0000988 protein binding transcription factor activity
1.49 2.22e-03 GO:0000989 transcription factor binding transcription factor activity
1.48 3.36e-03 GO:0003712 transcription cofactor activity
1.38 2.44e-04 GO:0019899 enzyme binding
1.34 3.65e-23 GO:0003676 nucleic acid binding
1.28 4.62e-08 GO:0008270 zinc ion binding
1.24 1.31e-06 GO:0003677 DNA binding
1.23 2.59e-33 GO:0005515 protein binding
1.22 4.05e-05 GO:0046914 transition metal ion binding
1.17 1.48e-02 GO:0000166 nucleotide binding
1.12 9.82e-31 GO:0005488 binding
1.12 1.98e-02 GO:0046872 metal ion binding
1.11 4.33e-02 GO:0043167 ion binding